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Neuromuscular Effects of Papuan Taipan Snake Venom Ann Neurol 38:916-920, Connolly,S.,et al, 1995 See this aricle in Pubmed Article Abstract Snakebite is a cause of significant morbidity in Central Province,Papua Ne Ginea.Three adult patients with clinical evidence of neurotoxicity following envenomation by the Papuan taipan had serial neurophysiological examinations over the course of their subsequent hospitalization.All required artificial ventilation for 2.5 to 5 days.The compound muscle action potential(CMAP)amplitudes declined over the first 2 to 4 days after envenoming and then gradually increased in parallel with clinical recovery.Repetitive stimulation studies revealed a distinctive pattern of abnormality.Activation resulted in brief potentiation of the CMAP followed by significantly greater decrement than observed at rest.This effect lasted up to 30 minutes and was not altered after intravenous edrophonium. Single-fiber electromyographic recordings during the recovery phase of the illness were abnormal with mared blocking and increased jitter.All patients were able to return home.

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(click to filter results - removes previous filter) bulbar palsy electromyogram muscle weakness neuromuscular blockade neuromuscular junction,abnormality of neurotoxin ophthalmoplegia pain,abdominal prognosis ptosis respiratory failure single-fiber electromyography subarachnoid hemorrhage,prognosis toxins,nervous system

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